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C4X Discovery

Better, Safer, Faster

C4X Discovery is rapidly establishing itself as a leading global company in the area of ligand-based design and drug development, driven by its unique NMR-based technology for solving the three-dimensional structures of drug structures. We have an expanding team of NMR spectroscopists and medicinal chemists and are always interested to hear from excellent candidates who believe they can contribute to our growth.

If you are interested submitting your curriculum vitae to C4X Discovery for consideration, then please email This email address is being protected from spambots. You need JavaScript enabled to view it. with a PDF copy of your CV and covering letter.

Employer: C4X Discovery Ltd
Position: Permanent Contract
Location: Manchester City Centre, UK
Salary: Competitive

C4X Discovery is a rapidly growing biotechnology company with a focus on ligand-based drug discovery. Using their unique proprietary NMR-based technology, C4X Discovery is able to determine the dynamic solution behaviour of biologically important molecules. This technology is being used to develop a portfolio of drug discovery projects.

C4X Discovery is seeking a self-motivated, adaptable individual to join their dynamic Chemistry team.

The Position:

The role of the Medicinal Chemist is to manage the synthesis, testing and analysis of compounds from C4X Discovery’s internal Drug Discovery portfolio.

Primary Duties:

  • Design novel small molecules with a view to optimising them to candidate drugs;
  • Utilise database and experimentally determined information to aid conformational analysis and design;
  • Identify and manage outsourcing partners, monitoring studies to ensure quality and timely reporting;
  • Interact with scientists in a multidisciplinary setting, including in vitro/in vivo biology, DMPK, structural biology and toxicology;
  • You may also be required to:
    • Support client projects
    • Attend conferences
    • Support patent protection of key chemistry assets
    • Support the continued development of C4X Discovery’s technology and its application

The Candidate:

C4X Discovery is looking to identify and recruit an experienced Medicinal Chemist with a demonstrable record of innovative science in drug discovery. The ideal candidate will have:

  • at least 5 years’ industry experience at an influential project level as a Medicinal Chemist in a Pharmaceutical or Biotechnology company;
  • enthusiasm for new technologies and methods of undertaking drug discovery;
  • positively impacted a range of drug discovery targets in either lead identification or lead optimisation;
  • experience utilising 3D structural data;
  • a strong track record of creative thinking when identifying novel solutions to problems;
  • excellent team-working skills with experience of working in and influencing multidisciplinary project teams;
  • the ability to lead scientific direction through collaboration and cross-functional interaction;
  • excellent organisational and communication skills.

Minimum qualifications:

  • Chemistry degree + 5 years industry experience
  • PhD + 3 years industry experience

If you feel that your skills and experience are aligned with the position, please email your CV and cover letter to This email address is being protected from spambots. You need JavaScript enabled to view it. 

The submission deadline is the 20th September 2015.

C4X Discovery is committed to equal opportunity employment and non-discrimination for all employees without regard to a person's race, colour, gender, age, religion, national origin, ancestry, disability or any characteristic protected under applicable law.

Copyright © 2015 C4X Discovery Holdings plc.
Registered in England and Wales with registered number 09134041.
Registered office: Manchester One, 53 Portland Street, Manchester M1 3LD, United Kingdom.

Medilink Business Awards 2013 - Innovation