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C4X Discovery

A new dimension in drug discovery

C4X Discovery is rapidly establishing itself as a leading global company in the area of ligand-based design and drug development, driven by its unique NMR-based technology for solving the three-dimensional structures of drug structures. We have an expanding team of NMR spectroscopists and medicinal chemists and are always interested to hear from excellent candidates who believe they can contribute to our growth.

If you are interested submitting your curriculum vitae to C4X Discovery for consideration, then please email This email address is being protected from spambots. You need JavaScript enabled to view it. with a PDF copy of your CV and covering letter.

Employer: C4X Discovery
Position: Permanent contract
Location: Manchester City Centre, UK
Application Deadline: 15th February 2015
Salary: £25,000 - £30,000 GBP / annum, plus benefits, dependent on experience

C4X Discovery is a rapidly growing biotechnology company with a focus on ligand-based drug discovery. We are currently looking to recruit solution-state NMR spectroscopists with strong chemistry backgrounds to join our successful R&D team. The chief activity is the 3D structure determination of small flexible molecules from NMR data using C4X Discovery's proprietary software tools. These structures provide the crucial data that enable truly rational ligand-based drug design to be realised, both for our in-house discovery programs and for our clients. Problem solving and an analytical mindset are very much required in this role, as is a willingness to work in a small multidisciplinary team. The successful candidate(s) will be expected to have the ability to deliver high quality and precise results to tight deadlines with minimal supervision, and possess strong analytical and communication skills.

Main Activities

  1. Determination of the 3D-structures of small flexible molecules from NMR data, which involves:
  2. -NMR sample preparation
    -Recording and processing of NMR spectra
    -Analysis using C4X Discovery's proprietary software tools

  3. Using the 3D-structures with the R&D team to identify and improve hit and lead drug molecules in our in-house discovery programs.
  4. Innovation of new protocols and methodologies for structure determination and analysis.
  5. Preparation of written reports and technical documentation packages on projects under the guidance of your supervisor.

Experience Required

  • Degree-level or equivalent in Chemistry (or Chemistry based subject) is essential.
  • Recently-acquired PhD in solution-state NMR is also essential.
  • Good computer literacy is essential. In particular, familiarity with Unix and molecular visualisation software would be advantageous.
  • Experience of chemical shift assignment and (protein) structure calculations is desirable.
  • Practical experience of Bruker NMR equipment.

Additional Key Skills

  • Learn quickly and work independently with minimal supervision.
  • Good organisational and time management skills.
  • Flexible and able to change priorities at short notice.
  • Able to work under pressure and meet deadlines.
  • Excellent word-processing and presentation skills.
  • Fluent in English and able to communicate results effectively.

Key Working Relationships

  • Head of NMR to manage program of work, training and professional development support.
  • Liaising with all members of the R&D team.
  • Liaise with R&D team and outside scientists to develop knowledge base and discuss ideas.

Open To: Applicants must be eligible to work in the specified location.


If you are interested in applying for this role and feel that you have the appropriate experience, then please email your CV in PDF format with a covering letter detailing the reasons for your suitability to: This email address is being protected from spambots. You need JavaScript enabled to view it.

C4X Discovery is committed to equal opportunity employment and non-discrimination for all employees without regard to a person's race, colour, gender, age, religion, national origin, ancestry, disability or any characteristic protected under applicable law.

Copyright © 2015 C4X Discovery Holdings plc.
Registered in England and Wales with registered number 09134041.
Registered office: Unit 310 Ducie House, Ducie Street, Manchester, M1 2JW, United Kingdom.

Medilink Business Awards 2013 - Innovation