Discover novel disease insights

Exploring data in a multivariate space allows for detection of disease heterogeneity and disease modifying genes.

Taxonomy3 PCA output

Taxonomy3 PCA output chart

Stratification driven by strong signal in chromosome D

Stratification driven by strong signal in chromosome D

Three patient subgroups detected in Parkinson’s Disease represented as distinct clusters in PCA plot driven by chromosome ‘D’. This locus contains a gene known to be involved in Parkinson’s Disease and set of genes responsible for the organism’s response to environment.

Target gene-disease prioritisation

Target gene-disease prioritisation Knowledge Graph

We developed a Knowledge Graph analytics platform integrating our proprietary Taxonomy3® results with publicly available data for efficient target prioritization and aggregation of evidence based on molecular, genetic and other omic data for hypothesis building. Taxonomy3® was co-developed with academic experts from the universities of Oxford and Lille and has been used in partnership with several of the world’s largest pharmaceutical companies, including Takeda and UCB Pharma. Multiple new targets in Rheumatoid Arthritis, Parkinson’s Disease, Alzheimer’s Disease and Ulcerative Colitis have been discovered using the technology.