Partnered Programmes
Further details on partnered drug discovery programmes
 

Oral Orexin-1 receptor antagonist programme for the treatment of Substance Abuse Disorders

We have successfully out-licensed our novel, oral Orexin-1 receptor antagonist (C4X_3256) to addiction market leaders Indivior, generating $10 million upfront and up to $284 million of potential development, regulatory and commercialisation milestones, in addition to royalties. Prior to deal signature, the pivotal pre-clinical GLP safety and toxicology studies were completed successfully and our partner Indivior is progressing this investigational drug towards initiation of the first clinical studies.

 

The Orexin-1 receptor is considered to be central to the brain’s “craving” and “reward” pathways with pre-clinical efficacy observed in multiple addiction models. Prior to the licensing deal with Indivior, we demonstrated that C4X_3256 attenuated cocaine-induced brain dopamine elevation supporting its potential in this important therapeutic area and adding to the compelling pre-clinical efficacy data already achieved in nicotine addiction showing reductions in self-administration and re-instatement.

In addition, our C4X_3256 programme was awarded a grant from the National Institute on Drug Abuse (“NIDA”, a division of National Institute of Health (“NIH”)) to support the investigation of the effects of C4X_3256 in cocaine addiction efficacy models extending the pre-clinical pharmacology package in parallel with clinical development.

 

Up to €414 million Exclusive Worldwide Licensing Agreement with Sanofi for C4XD oral IL-17A inhibitor programme

 

We have signed an exclusive worldwide licensing agreement with Sanofi (NASD: SNY, PAR: SAN - "Sanofi "), worth up to €414 million, for C4XD’s oral pre-clinical IL-17A inhibitor programme.  Under the terms of the agreement, C4XD will receive an upfront payment of €7 million and could receive up to a further €407 million in potential development, regulatory and commercialisation milestones, of which €11 million is in pre-clinical milestones, in addition to single digit royalties.

Interleukin-17 (“IL-17”) is a high value clinically validated target for inflammation and autoimmune diseases such as psoriasis (estimated to be worth $9 billion per annum). Our programme identified small molecules that can selectively block IL-17 activity whilst keeping the molecular size of the molecule in the traditional “drug-like” range. We have completed optimisation of our lead novel oral compounds which have shown that they can inhibit the release of IL-17 induced cytokines in the blood in vivo when administered orally prior to IL-17 administration. Current marketed drugs that target IL-17 are based on injectable monoclonal antibodies so an oral treatment would increase the number of patients who can access drugs targeting this mechanism and offer the pharmaceutical industry an alternative treatment regime.