Drug Discovery Pipeline
Highly Valuable Markets

C4X Discovery is using its unique proprietary technologies to build a pipeline of high quality small molecule drug candidates addressing valuable markets with high unmet medical need.

C4XD-pipeline

Since IPO in October 2014, C4X Discovery has been growing it’s drug discovery pipeline and now has 8 drug discovery programmes targeted in the therapeutics areas of Addiction, Diabetes, Chronic Obstructive Pulmonary Disease, Psoriasis, Oncology (including immuno-oncology) and Rheumatoid Arthritis.

Recently, Taxonomy3® has identified multiple novel targets in discrete patient subgroups for the treatment of Parkinson’s Disease that could potentially provide an opportunity in stratified medicine. The Company has recently reproduced the analysis from a second patient dataset confirming this discovery. The selection process to choose the first target to be prosecuted in a drug discovery programme is now underway with the expectation of initiating at least one programme by the end of the year.

Further genetic dataset analysis is underway in other neurodegenerative and inflammatory disorders with the aim of discovering novel drug targets to expand the pipeline further.

Information on selected drug discovery programmes is below.

ADDICTION

Hot GPCR targets lacking target protein crystal structure at project initiation

OREXIN-1 ANTAGONIST
($13bn)1

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Diabetes

Hot GPCR targets lacking target protein crystal structure at project initiation

GPR142 AGONIST
($55bn)3

Marketed Biologics (clinically validated) with small molecule opportunity

GLP-1 AGONIST
($55bn)3

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Inflammation

Intracellular target protein structure available, less tractable to conventional screening but enabled by C4X

NRF-2, COPD
($41bn)2

Marketed Biologics (clinically validated) with small molecule opportunity

ANTI-IL-17, PSORIASIS
($9bn)4

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Oncology

Intracellular target protein structure available, less tractable to conventional screening but enabled by C4X

SGC COLLABORATION
(Inititated Nov 15)

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  1. Market size in 2018; Source: GBI Research 2012
  2. Market size in 2017; Source: Visiongain, Asthma and COPD Therapies: World Market 2013-2023
  3. Market size in 2017; Source: Visiongain, Diabetes-Treatments-World-Drug-Market-2013-2023
  4. Market size in 2018; Source Visiongain, Psoriasis Treatment; Decision Resources
c4xd pipeline hot gpcr g

Hot GPCR targets lacking target protein crystal structure at project initiation

c4xd pipeline biologicals g

Marketed Biologics (clinically validated) with small molecule opportunity

c4xd pipeline intracellular g

Intracellular target protein structure available, novel hit finding less successful with conventional screening but enabled by C4X